Getting Started with Sexual Health Peptides

Ready to enhance your sexual health with peptides? This comprehensive guide walks you through every step, from determining eligibility to optimizing results.

Whether you're considering PT-141, Oxytocin, Kisspeptin, or other peptides, this guide provides everything you need to know to start safely and effectively.

Step 1: Determine Your Eligibility

1 Assess Your Sexual Health Concerns

For Women

✓ You May Benefit If You Experience:

Low sexual desire (HSDD) - lack of interest in sex
Difficulty becoming aroused
Trouble achieving orgasm or reduced intensity
Distress about your sexual function
Sexual dysfunction affecting your relationship

For Men

✓ You May Benefit If You Experience:

Erectile dysfunction (difficulty achieving/maintaining erections)
Low sexual desire or interest
Performance anxiety
Low testosterone symptoms
Inability to use Viagra/Cialis due to heart disease

⚠️ Contraindications

Do NOT use sexual health peptides if you have:

Uncontrolled high blood pressure (especially for PT-141)
Severe cardiovascular disease (consult cardiologist first)
Pregnancy or breastfeeding (insufficient safety data)
History of priapism (prolonged erections)
Severe liver or kidney disease

Step 2: Choose Your Provider

2 Find a Qualified Healthcare Provider

Provider Options

Provider Type	Pros	Cons	Cost
Sexual Health Specialist	Expert knowledge, comprehensive care	May have long wait times	$200-500 initial consult
Telehealth Peptide Clinic	Convenient, fast, specialized	No insurance coverage	$100-300 consult
Primary Care Physician	Established relationship, insurance	May not be familiar with peptides	$50-150 with insurance
Urologist (Men)	ED expertise, comprehensive testing	May prefer traditional treatments	$150-400 initial visit
Gynecologist (Women)	Women's health expertise	May not be familiar with peptides	$100-300 initial visit

💡 What to Look For

Experience with peptide therapy
Willingness to prescribe PT-141 or other peptides
Comprehensive approach (not just prescribing)
Good communication and patient education
Reasonable pricing and transparency

Step 3: Initial Consultation

3 Complete Medical Evaluation

What to Expect

Your provider will conduct a comprehensive evaluation:

✓ Medical History Review

Sexual health history and current concerns
Relationship status and partner communication
Current medications and supplements
Medical conditions (diabetes, heart disease, etc.)
Mental health history (depression, anxiety)
Lifestyle factors (stress, sleep, exercise)

✓ Physical Examination

Blood pressure measurement
General physical exam
Genital examination (if indicated)
Cardiovascular assessment

✓ Laboratory Tests (Usually Required)

For Men: Testosterone (total and free), LH, FSH, prolactin, thyroid (TSH), glucose/HbA1c
For Women: Estrogen, progesterone, testosterone, thyroid (TSH), prolactin
For Both: Complete blood count, comprehensive metabolic panel

Questions to Ask Your Provider

Which peptide do you recommend for my situation and why?
What's your experience prescribing sexual health peptides?
Will you prescribe FDA-approved Vyleesi or compounded PT-141?
What results should I realistically expect?
How will we monitor for side effects?
What's the plan if peptides don't work?
Can I combine peptides with other treatments?
What's the total cost including follow-ups?

Step 4: Starting Your Peptide

4 Obtain and Prepare Your Medication

Getting Your Prescription

FDA-Approved PT-141 (Vyleesi):

Prescription: Required from licensed provider
Pharmacy: Specialty pharmacy or local pharmacy
Cost: $900-1,000 per month (4 doses)
Insurance: Limited coverage, manufacturer coupon may reduce to $25-50/dose
Form: Pre-filled auto-injector pens

Compounded Peptides:

Cost: $50-200 per month
Source: Compounding pharmacy or peptide clinic
Form: Vials requiring reconstitution or pre-filled syringes
Quality: Variable, not FDA-approved

First Dose Guidelines

Peptide	Starting Dose	Timing	What to Expect
PT-141 (Women)	1.75mg SubQ	2-4 hours before	Possible nausea, increased desire in 2-6 hours
PT-141 (Men)	1.0-1.5mg SubQ	1-3 hours before	Possible nausea, erections in 1-4 hours
Oxytocin	24-40 IU nasal	30-60 min before	Increased bonding feelings, minimal side effects
Kisspeptin	1mcg/kg SubQ	2-3x per week	No immediate effects, works over 2-4 weeks

💡 Injection Tips

Site: Abdomen (2 inches from belly button) or thigh
Technique: Pinch skin, insert at 45-90 degrees, inject slowly
Rotation: Alternate sites to prevent irritation
Timing: Plan ahead - PT-141 takes 2-4 hours to work
Storage: Refrigerate unopened vials, room temp for in-use

Step 5: Managing Side Effects

5 Minimize and Manage Side Effects

Common Side Effects by Peptide

Peptide	Common Side Effects	Management
PT-141	Nausea (40%), flushing (20%), headache (11%)	Anti-nausea med 30 min before, light meal, hydration
Melanotan-II	Nausea (50%), flushing (30%), skin darkening	Start very low dose, anti-nausea med, expect tanning
Oxytocin	Minimal (nasal irritation occasionally)	Saline nasal spray if needed
Kisspeptin	Minimal (occasional headache)	OTC pain reliever if needed

Minimizing Nausea (PT-141/Melanotan-II)

Anti-nausea medication: Ondansetron 4-8mg, 30 minutes before injection
Light meal: Eat something small 1 hour before
Ginger: Ginger tea or supplements
Timing: Inject in evening so nausea occurs during sleep
Lower dose: Start with 50-75% of recommended dose
Tolerance: Nausea typically decreases with repeated use

⚠️ Seek Medical Attention If:

Priapism: Erection lasting >4 hours (medical emergency)
Severe blood pressure increase: Headache, vision changes, chest pain
Allergic reaction: Difficulty breathing, swelling, severe rash
Persistent vomiting: Unable to keep down fluids

Step 6: Optimizing Results

6 Maximize Your Success

Lifestyle Optimization

Sleep: 7-9 hours per night (critical for hormones)
Exercise: 150+ minutes per week (improves blood flow and hormones)
Stress management: Meditation, therapy, work-life balance
Weight management: Lose excess weight (improves function)
Limit alcohol: Reduces sexual function
Quit smoking: Improves vascular function

Relationship & Communication

Partner involvement: Discuss peptide use and expectations
Reduce pressure: Focus on intimacy, not just performance
Timing coordination: Plan ahead for PT-141's 2-4 hour onset
Couples therapy: Address underlying relationship issues
Mindfulness: Be present during intimacy

Combining Treatments

Peptides can be safely combined with other treatments:

PT-141 + Viagra/Cialis: Synergistic for ED (monitor BP)
PT-141 + Oxytocin: Desire + emotional connection
Kisspeptin + PT-141: Long-term hormones + acute enhancement
Peptides + Therapy: Address psychological components
Peptides + Hormone Optimization: Comprehensive approach

Step 7: Monitoring & Adjustment

7 Track Progress and Adjust Protocol

What to Monitor

Effectiveness: Improvement in desire, arousal, function
Side effects: Frequency and severity
Optimal dose: Lowest effective dose
Timing: Best time to inject for your schedule
Blood pressure: Especially with PT-141
Hormone levels: If using Kisspeptin/Gonadorelin

When to Adjust

Insufficient results: Increase dose by 25-50%
Excessive side effects: Decrease dose by 25-50%
Tolerance developing: Take breaks or rotate peptides
No improvement after 4-6 uses: Try different peptide or combination

Follow-Up Schedule

Week 2: Check-in on side effects and initial results
Month 1: Assess effectiveness, adjust dose if needed
Month 3: Comprehensive evaluation, labs if using Kisspeptin
Every 3-6 months: Ongoing monitoring and optimization

⚠️ Medical Disclaimer

This guide provides educational information only. Sexual health peptides require medical supervision. Consult with a qualified healthcare provider before starting any peptide therapy. Individual results vary based on underlying causes, overall health, and adherence to protocols.

Women's Guide → Men's Guide →